This animated horror-comedy series follows one Mark Lilly, social worker at the Department of Integration, as he helps new citizens both human and “other” adapt to hectic life in the Big Apple. There are easier tasks than weaning vampires off of blood, socializing land-whales, and housebreaking werewolves, but Mark is up to the challenge. Between his stressful job, a zombie roommate, and a demon ex-girlfriend, Mark’s lucky if he can sneak in a few minutes of sleep. But who can sleep when there’s a drop-dead gorgeous Mermaid sitting at the bar?
With the big company intramural football game around the corner, everyone starts getting nervous about the lineup -- Mark is a wonderful team player, but a terrible actual player. When Randall demonstrates the power of his recently replaced arm, he is given a job at the D.O.I. as the team's ringer.
An ant-sized arsonist named Jerry flees Mark's custody, escaping up Twayne's nostril. A miniaturized Leonard, Grimes and Mark must track Jerry through Twayne's body to bring him to justice.
With Mark working all the time, Randall feels neglected, so he decides that they should spend more time together to decide if they should stay roommates. And Grimes’s Mummy returns from the dead, only to find fault with everything Grimes is doing.
Callie reveals to Mark that she's been sleeping with other guys. A girlfriend from Marks past returns, with a dark secret.
Twayne throws a company party aboard a cruise ship; Randall gets sick from dangerous pollen.