This animated horror-comedy series follows one Mark Lilly, social worker at the Department of Integration, as he helps new citizens both human and “other” adapt to hectic life in the Big Apple. There are easier tasks than weaning vampires off of blood, socializing land-whales, and housebreaking werewolves, but Mark is up to the challenge. Between his stressful job, a zombie roommate, and a demon ex-girlfriend, Mark’s lucky if he can sneak in a few minutes of sleep. But who can sleep when there’s a drop-dead gorgeous Mermaid sitting at the bar?
With Mark working all the time, Randall feels neglected, so he decides that they should spend more time together to decide if they should stay roommates. And Grimes’s Mummy returns from the dead, only to find fault with everything Grimes is doing.
Callie reveals to Mark that she's been sleeping with other guys. A girlfriend from Marks past returns, with a dark secret.
Twayne throws a company party aboard a cruise ship; Randall gets sick from dangerous pollen.
Randall puts Mark's soul up for sale, Grimes pursues his dream of creating a pop music act with a teen sensation.
Callie creates clones of Mark to win a bowling tournament. But Mark's Clone finds a message in Callie's diary, and decides to get revenge by framing her for murder.